Researchers at the University of Campinas in Brazil conducted experiments with obese mice for a week to investigate the effects of strength training on fat cells before weight loss began. When people gain weight, many biological changes occur in the body, so it can be difficult for researchers trying to measure the effects of nutrition, exercise, or any other factor, to separate these effects from what they are trying to measure. The researchers wanted to clarify the effects of strength training on fat cells before weight loss began, so they looked at the visceral (inner) fat around the organs of the mice before the animals lost weight. link
Compared to sedentary obese mice, the mice that were put on a strength training program had less fat around their intestines and smaller cells, which usually indicate healthier fat tissue. Positive changes were also observed in fat storage and fat breakdown signals.


The results of the study, published in Life Sciences, show that strength training improves metabolic health before any weight loss; however, the findings need to be replicated in human studies. link
“People have been doing strength training for two months but if they don’t lose weight, they think it’s useless,” says obesity surgery expert Leandro Moura. “But what we saw in this study was that, even after just seven days of strength training – without any weight loss – the molecular pathways that promote fat accumulation were less active, while those that stimulate fat breakdown were more active.”
In addition to the benefits described above, the team also looked at two proteins, ABHD5 and ATGL. ABHD5, one of the proteins that directs the breakdown of fats, was reduced in levels in obese and sedentary mice, while in the strength training group, ABHD5 levels were normal and there was also an increase in interactions with ATGL, an enzyme that breaks down fats. When the suppression of the Scd1 gene, which plays a role in fat production, was added in mice that exercised, the researchers say there is evidence that strength training, combined with aerobic exercise, may work to promote weight loss.
The research has been published. This article has been verified by Fiona MacDonald (link) and edited by MacDonald (link). We are proud of our process, but we are only human; if you spot an error, please let us know (link).




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